49ers vs. Cowboys odds, spread, line: Sunday Night Football picks ...

The San Francisco 49ers (4-0) will host the Dallas Cowboys (3-1) in a primetime battle on Sunday Night Football. These are two of the top teams in the NFC thus far. The all-time series is tied 19-19-1 but the 49ers have had more success in recent years. In fact, San Francisco has knocked the Cowboys out of the playoffs in each of the last two seasons. The 49ers are currently third in the NFL in scoring (31.3), with Dallas sitting in the fourth spot (31). 

Kickoff is set for 8:20 p.m. ET. San Francisco is a 3.5-point favorite in the latest 49ers vs. Cowboys odds, while the over/under for total points scored is 45. Before making any Cowboys vs. 49ers picks or predictions, you need to see what proven SportsLine NFL expert Micah Roberts has to say, given his mastery of picks involving San Francisco.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He has a particularly keen eye for the 49ers, going 18-5 on his NFL picks involving 49ers, returning $1,250 to $100 bettors. Anyone who has followed his advice is way up. 

Now, Roberts has locked in on Cowboys vs. 49ers from every angle and just locked in his picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and betting lines for 49ers vs. Cowboys: 

49ers vs. Cowboys spread: San Francisco -3.549ers vs. Cowboys over/under: 45 points 49ers vs. Cowboys money line: San Francisco -182, Dallas +153DAL: Cowboys are 9-1 ATS in their last 10 games played in OctoberSF: 49ers are 3-1 ATS in their last five games 49ers vs. Cowboys picks: See picks at SportsLine49ers vs. Cowboys live stream: fubo (try for free)Why the 49ers can cover

San Francisco thrives on the defensive side of the ball. The 49ers are presently fifth in the NFL in total defense (284.3) and third in run defense (66). Linebacker Fred Warner is a disruptive and natural difference-maker. Warner flies to the play and has quick feet in coverage. The two-time Pro Bowl selection leads the team in total tackles (33) with two tackles for loss and two pass deflections. In his last outing, Warner had 10 total tackles. 

Defensive tackle Javon Hargrave joined San Francisco in the offseason. Hargrave has terrific play recognition skills and powerful hands. The 30-year-old is first on the team in sacks (3) with 11 total tackles. Defensive end Nick Bosa is a pure and explosive pass rusher. Bosa owns an outstanding pass-rush plan with an elite get-off. In 2022, the Ohio State product led the league in sacks (18.5). See which team to back here.

Why the Cowboys can cover

Dallas is second in the NFL in total defense (259.8) and pass defense (148). Since 2022, the Cowboys have generated the most turnovers (43) in the league. This group has allowed 10 or fewer points in three of their four games. Linebacker Micah Parsons is a relentless and effective defender. Parsons explodes off the snap and has a pass-rush plan that is extremely effective.

The Penn State product is tied for sixth in sacks (four) with 14 total tackles and six tackles for loss. Linebacker Leighton Vander Esch is an alert and athletic defender in the middle of the field. Vander Esch sniffs out the run and has the skill set to defend in space. The 27-year-old is second on the team with 20 total tackles and one fumble recovery. See which team to back here.

How to make Cowboys vs. 49ers picks

Roberts has analyzed this matchup from every angle and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

Who wins Cowboys vs. 49ers on Sunday Night Football, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Cowboys vs. 49ers spread hits hard, all from the expert who is 18-5 on picks involving San Francisco, and find out.