Packers vs. 49ers prediction, odds, line, spread: 2024 NFL playoff ...

The San Francisco 49ers are ready to start their run at the Super Bowl, but the red-hot Green Bay Packers will be the first obstacle in Saturday's NFL Divisional Round matchup. The 49ers (12-5) should be refreshed after getting a week off after earning the NFC's top seed. They also were able to rest most of their starters in a meaningless 21-20 loss to the Rams in Week 18. The Packers (10-8) earned their spot in the NFL Divisional Round with a stunning 48-32 victory in Dallas last Sunday. The teams have met nine times in the postseason, the most common playoff matchup since the merger, and the 49ers are 5-4 and have won four straight.

Saturday's kickoff in Santa Clara, Calif., is set for 8:15 p.m. ET. The latest Packers vs. 49ers odds list San Francisco as a 10-point favorite, and the over/under for total points scored is 50.5. Before making any 49ers vs. Packers picks, make sure you check out what SportsLine NFL expert R.J. White has to say, given his mastery of picks in games involving the Packers.

White, a fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and went 535-450-30 on his ATS picks from 2017-22, which returned more than $3,500 to $100 players. He also closed the 2022 NFL season on an incredible 107-80-6 run on his last 193 against-the-spread and total NFL picks, returning more than $1,800 for $100 bettors.

What's more, White is an incredible 66-27-2 on his last 95 picks involving the Packers for a profit of $3,457 for $100 bettors. Anyone who has followed him is way up.

Now, White has set his sights on Packers vs. Niners and just locked in his picks and NFL predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Niners vs. Packers:

Packers vs. 49ers spread: San Francisco -10Packers vs. 49ers over/under: 50.5 pointsPackers vs. 49ers money line: San Francisco -479, Green Bay +363GB: Packers are 4-1 against the spread in their last five divisional playoff matchupsSF: 49ers are 7-2 ATS in nine playoffs games under Kyle ShanahanPackers vs. 49ers picks: See picks at SportsLinePackers vs. 49ers live stream: fubo (try for free)  Why the 49ers can cover

San Francisco is 12-6 against the spread as a home favorite over the past two seasons and has proven all season it is one of the league's most well-rounded teams. The 49ers score 28.9 points per game and give up 17.5, with both marks ranking third in the NFL. They also are plus-10 in turnover margin, while the Packers are even. With two MVP candidates in the backfield and a bevy of talented pass-catchers, the San Francisco offense is a matchup nightmare for defenses.

NFL rushing champion Christian McCaffrey (1,459 yards) will face a Packers defense that allows 128 rushing yards per game (28th in NFL). If Green Bay sells out to contain McCaffrey, quarterback Brock Purdy (4,281 yards, 31 TDs) can make them pay. Purdy has two 1,000-yard receivers - Brandon Aiyuk (1,342) and tight end George Kittle (1,020). Versatile receiver Deebo Samuel (1,117 total yards) is also tough to stop, and McCaffrey also has 562 receiving yards. See which team to pick here. 

Why the Packers can cover

Green Bay is a young team that has no fear, which was evident when the Packers became the first team to beat the Cowboys at home this season. They are 7-4 against the spread as underdogs, winning the past four outright. Quarterback Jordan Love threw for 272 yards and three touchdowns last Sunday and running back Aaron Jones rushed for 118 and three scores. Love has 21 passing TDs and one interception over the past nine games, and Jones has four straight over 100 rushing yards.

The 49ers are loaded, but could show rust after having a bye on Wild Card Weekend and sitting most of their starters in Week 18. They are vulnerable to the pass, ranking 14th in the NFL, and Green Bay has talented young pass-catchers. Second-year pro Romeo Doubs had 151 receiving yards last week, and rookie tight end Luke Musgrave had 52 yards and a TD on just three receptions. The defense had four sacks and two takeaways against the Cowboys. See which team to pick here. 

How to make Packers vs. 49ers picks

White has analyzed this matchup and is leaning Over the point total, but he has discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

Who wins 49ers vs. Packers in the 2024 NFL playoffs, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the 49ers vs. Packers spread to back, all from the expert on a 66-27 roll on picks involving Green Bay.